Personalized medicine: Genetic risk prediction of drug response
نویسندگان
چکیده
منابع مشابه
Prediction of Cancer Drug Resistance and Implications for Personalized Medicine
Drug resistance still impedes successful cancer chemotherapy. A major goal of early concepts in individualized therapy was to develop in vitro tests to predict tumors' drug responsiveness. We have developed an in vitro short-term test based on nucleic acid precursor incorporation to determine clinical drug resistance. This test detects inherent and acquired resistance in vitro and transplantabl...
متن کاملPersonalized medicine: risk prediction, targeted therapies and mobile health technology
Personalized medicine is increasingly being employed across many areas of clinical practice, as genes associated with specific diseases are discovered and targeted therapies are developed. Mobile apps are also beginning to be used in medicine with the aim of providing a personalized approach to disease management. In some areas of medicine, patient-tailored risk prediction and treatment are app...
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personalized medicine aims is to supply the proper drug to the proper patient within the right dose. pharmacogenomics (pgx) is to recognize genetic variants that may influence drug efficacy and toxicity. all things considered, the fields cover a wide area, including basic drug discovery researches, the genetic origin of pharmacokinetics and pharmacodynamics, novel drug improvement, patient gene...
متن کاملThe Cost-Effectiveness of Personalized Genetic Medicine
OBJECTIVE Neonatal diabetes mellitus is a rare form of diabetes diagnosed in infancy. Nearly half of patients with permanent neonatal diabetes have mutations in the genes for the ATP-sensitive potassium channel (KCNJ11 and ABCC8) that allow switching from insulin to sulfonylurea therapy. Although treatment conversion has dramatic benefits, the cost-effectiveness of routine genetic testing is un...
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Cancer, as we now know, is a genetic disease. This knowledge entails that to enable evidence-based personalized diagnosis for any patient, the location of where the tumor occurs (e.g. brain, liver, etc.) is less relevant than the underlying genetic signature that the cancer cells express (i.e. whether genes are silenced, amplified or mutated). With the advent of high-throughput gene sequencing ...
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ژورنال
عنوان ژورنال: Pharmacology & Therapeutics
سال: 2017
ISSN: 0163-7258
DOI: 10.1016/j.pharmthera.2017.02.036